WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Hepatitis C       ID:05160
C=134; O=10; E=0.20; R=49.51; rawP=9.22e-15; adjP=7.38e-14
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107201 NA DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 23586 ENSG00000107201
2  ENSG00000111335 NA OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 4939 ENSG00000111335
3  ENSG00000164342 NA TLR3 toll-like receptor 3 7098 ENSG00000164342
4  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415
5  ENSG00000213928 NA IRF9 interferon regulatory factor 9 10379 ENSG00000213928
6  ENSG00000185507 NA IRF7 interferon regulatory factor 7 3665 ENSG00000185507
7  ENSG00000111331 NA OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 4940 ENSG00000111331
8  ENSG00000185745 NA IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3434 ENSG00000185745
9  ENSG00000089127 NA OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 4938 ENSG00000089127
10  ENSG00000170581 NA STAT2 signal transducer and activator of transcription 2, 113kDa 6773 ENSG00000170581


Database:KEGG pathway       Name:RIG-I-like receptor signaling pathway       ID:04622
C=71; O=5; E=0.11; R=46.72; rawP=8.01e-08; adjP=3.20e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107201 NA DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 23586 ENSG00000107201
2  ENSG00000185507 NA IRF7 interferon regulatory factor 7 3665 ENSG00000185507
3  ENSG00000108771 NA DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 79132 ENSG00000108771
4  ENSG00000115267 NA IFIH1 interferon induced with helicase C domain 1 64135 ENSG00000115267
5  ENSG00000187608 NA ISG15 ISG15 ubiquitin-like modifier 9636 ENSG00000187608


Database:KEGG pathway       Name:Cytosolic DNA-sensing pathway       ID:04623
C=56; O=3; E=0.08; R=35.54; rawP=8.55e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107201 NA DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 23586 ENSG00000107201
2  ENSG00000160710 NA ADAR adenosine deaminase, RNA-specific 103 ENSG00000160710
3  ENSG00000185507 NA IRF7 interferon regulatory factor 7 3665 ENSG00000185507


Database:KEGG pathway       Name:Toll-like receptor signaling pathway       ID:04620
C=102; O=3; E=0.15; R=19.51; rawP=0.0005; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000185507 NA IRF7 interferon regulatory factor 7 3665 ENSG00000185507
2  ENSG00000164342 NA TLR3 toll-like receptor 3 7098 ENSG00000164342
3  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415


Database:KEGG pathway       Name:Osteoclast differentiation       ID:04380
C=128; O=3; E=0.19; R=15.55; rawP=0.0010; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170581 NA STAT2 signal transducer and activator of transcription 2, 113kDa 6773 ENSG00000170581
2  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415
3  ENSG00000213928 NA IRF9 interferon regulatory factor 9 10379 ENSG00000213928


Database:KEGG pathway       Name:Jak-STAT signaling pathway       ID:04630
C=155; O=3; E=0.23; R=12.84; rawP=0.0017; adjP=0.0023
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170581 NA STAT2 signal transducer and activator of transcription 2, 113kDa 6773 ENSG00000170581
2  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415
3  ENSG00000213928 NA IRF9 interferon regulatory factor 9 10379 ENSG00000213928


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=2; E=0.28; R=7.02; rawP=0.0332; adjP=0.0379
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170581 NA STAT2 signal transducer and activator of transcription 2, 113kDa 6773 ENSG00000170581
2  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=2; E=1.70; R=1.17; rawP=0.5108; adjP=0.5108
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134326 NA CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 129607 ENSG00000134326
2  ENSG00000002549 NA LAP3 leucine aminopeptidase 3 51056 ENSG00000002549




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).